Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons
Myelination of axons by oligodendrocytes is a key feature of the remarkably fast operating CNS.Oligodendrocytes not only tune axonal conduction speed but are also suggested to maintain long-term axonal integrity by providing metabolic support to the axons they ensheath.However, how myelinating oligodendrocytes impact axonal energy homeostasis remai